Rishabh Singh/X
Sep 18, 2025, 07:00
Rishabh Singh on NEJM Letter: FVIII Aurora Mutation Shows Increased Activity and Reduced APC Response
Rishabh Singh, an Heme/Onc fellow at Indiana University, posted on X:
“In a letter to the editor of NEJM, authors describe a naturally occurring FVIII variant, Arg590Ser (designated FVIII Aurora), with substantially increased activity and reduced responsiveness to activated protein C as compared with wild-type FVIII.”
Title: A Naturally Occurring Gain-of-Function Mutation in Factor VIII
Authors: Joshua T. Wischmeyer, Christine H. Baird, Julian Grandvallet Contreras, Alexander Tran, Tzu Phang, Tian Liu, Marilyn J. Manco-Johnson
Read the full version here.
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