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Early Aspirin Withdrawal After PCI in ACS: NEO-MINDSET and TARGET Trials
Sep 20, 2025, 15:07

Early Aspirin Withdrawal After PCI in ACS: NEO-MINDSET and TARGET Trials

Christopher Cannon, Senior Physician in the Cardiovascular Division at Brigham and Women’s Hospital, shared a post on LinkedIn:

”Keep the ASA for the first 12 months post ACS PCI.
The NEO-MINDSET trial found that early stopping and keeping P2Y12 monotherapy was NOT sufficient for efficacy.
Of note, another study published, the TARGET First looked at “low risk” STEMI patients and suggested one could stop ASA, but it appeared to have much less power with just 41 primary endpoints.
So – I will aim to keep DAPT for a year post PCI for ACS. (although sometimes one has to adapt for very high risk bleeding patients).”

Title: Early Withdrawal of Aspirin after PCI in Acute Coronary Syndromes

Authors: Patricia O. Guimarães, Marcelo Franken, Caio A.M. Tavares, Murillo O. Antunes, Fabio S. Silveira, Pedro B. Andrade, Ricardo R. Bergo

Aspirin

Read the full article here.

Find more on Hemostasis Today.