Surbhi Singh/LinkedIn
Oct 28, 2025, 06:54
Surbhi Singh: Hypersegmented Neutrophils – The Overachievers of the Myeloid World
Surbhi Singh, Consultant Haematopathology at Agilus Diagnostics and Fortis Hospital Gurugram, shared a post on LinkedIn:
“Hypersegmented Neutrophils
Meet the overachievers of the myeloid world!
Neutrophils with ≥5 lobes, flagging a nuclear maturation defect — most classically in megaloblastic anemia (B12 or folate deficiency) when the nucleus keeps dividing but the cytoplasm doesn’t keep pace.
Clue: If more than 5% of neutrophils have 5 lobes or any one neutrophil has ≥6 — time to think B12/folate deficiency.
Other Causes of Hypersegmented Neutrophils
- Myelodysplastic syndromes (MDS)
- Chemotherapy / cytotoxic drugs (e.g., methotrexate, hydroxyurea)
- DNA synthesis inhibitors (e.g., azathioprine, 5-FU)
- Chronic infections / inflammation
- Congenital neutrophil disorders (rare)
- Uremia (occasionally)
- Alcoholism / liver disease (nutritional + marrow toxicity factors).”
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