Natasha Jolakoski on Rethinking Lead-in Strategies in VTE
Natasha Jolakoski, PGY-2 Thrombosis and Hemostasis Resident at The University of New Mexico Hospital, shared on LinkedIn:
”I’m excited to share that our multicenter study, “Rethinking lead-in strategies: evaluation of full vs. reduced-dose factor Xa inhibitors in acute VTE,” has been published in the Journal of Thrombosis and Thrombolysis.
This study evaluated bleeding and thrombotic outcomes associated with reducing factor Xa inhibitor lead-in duration in patients who received prior parenteral anticoagulation, across 1,400+ patients with acute VTE.
We found that a reduced lead-in approach was not associated with higher rates of VTE recurrence or major bleeding.
I’d like to thank my preceptors, Stephanie Edwin and Christopher Giuliano , for their guidance and support throughout this project, as well as all the co-authors who made this collaboration possible.”
Read the full article here.
Article: Rethinking lead-in strategies: evaluation of full vs. reduced dose factor Xa inhibitors in acute VTE
Authors: Natasha Jolakoski, Sarah Grazia, Clare Brewster, Brehanna Edwards, Danielle Rosas, Diana Penev, Whitney Anderson, Stephanie B. Edwin, Shannon Carabetta, Bradley Haan, Thomas Breedan, Megan Laux, Kathaleen Watson, Andrew Harpenau, Rachel Bruns, Josephine Varda, Kathleen Koopman, Meagan Paylor, Christopher Guiliano

Stay updated on all scientific advances with Hemostasis Today.
-
Mar 18, 2026, 16:34Richard Buka: Exploring the COBRRA Trial in the Latest Episode of Don’t Just Read the Abstract
-
Mar 18, 2026, 16:22Heghine Khachatryan: Navigating the New Era of Hemophilia Gene Therapy
-
Mar 18, 2026, 16:21Georges Chahoud: Top Take-Home Messages from the AHA/ACC/Multisociety Acute PE Guideline
-
Mar 18, 2026, 16:19Cedric Hermans: Unleashing the Potential of Physical Activity in Hemophilia A Patients
-
Mar 18, 2026, 16:17Asif Mushtaq: Managing Cardiac Surgery with Cardiopulmonary Bypass in Hemophilia
-
Mar 18, 2026, 16:15Amir Kraitzer: Engineering Hemocompatible Surfaces to Overcome Thrombosis in Medical Devices
-
Mar 18, 2026, 16:11Hemant Sharma: Advancing Neonatal Care with New Strategies to Prevent IVH
-
Mar 18, 2026, 16:09Yves Bikorimana: How a Simple Temperature Change Can Trigger Antibody-Mediated Destruction of RBCs
-
Mar 18, 2026, 16:07Scott Isaacs: Optimizing Brain Vitality and Slowing Neurodegeneration Through Daily Habits