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Dec 25, 2025, 03:54

Davide Stradella: Bleeding is an Unpleasant Complication in Endoscopy

Davide Stradella, Consultant Physician (Gastroenterology and Digestive Endoscopy) at Mauriziano Hospital, Turin, shared a post on LinkedIn:

“We need to ensure safety for our patients in every day practice and operative endoscopy.
Bleeding is a unpleasant complication in endoscopy.
We need to know MoA and correct time for withdrawal of principal antiplatelets/anticoagulant

Here’s a Antiplatelets & anticoagulants in endoscopy — practical update for daily practice based on principal guidelines and review.

Balancing bleeding vs thrombotic risk is central to safe endoscopy. Short summary:
• Diagnostic procedures (EGD/colonoscopy without biopsy, ERCP without sphincterotomy): usually do not stop aspirin/warfarin/DOACs — omit morning DOAC dose for low-risk cases.
• High-risk procedures (EMR/ESD, polypectomy >1–2 cm, sphincterotomy): stop P2Y12 inhibitors 5–7 days (clopidogrel/ticagrelor ~5 days, prasugrel ~7), stop warfarin 5 days and ensure INR <1.5, and stop DOACs 48–72 h before (longer if renal impairment). Continue aspirin in most cases. Liaise with cardiology for recent coronary stent/DAPT.
• Urgent bleeding / life-threatening cases: use specific reversal agents where indicated (idarucizumab for dabigatran; andexanet alfa or PCCs for factor-Xa inhibitors) and coordinate with hematology/cardiology.

Short practical tip: document thrombotic risk (stent timing, mechanical valve, recent VTE/AF CHADS-VASc), classify procedure bleed-risk, and have plan for interruption/resumption and for urgent reversal.

1. BSG/ESGE guideline — Endoscopy in patients on antiplatelet or anticoagulant therapy (update 2021; addendum 2024). (full guideline PDF).
2. Veitch AM et al., Gut / Endoscopy (BSG/ESGE summary 2021).
3. ACG/CAG clinical guideline on periprocedural antithrombotic management (2022).
4. International Digestive Endoscopy Network (IDEN) consensus on antithrombotics in endoscopy (2024).
5. Reviews on anticoagulant reversal and peri-endoscopic management (2021–2024).”

Davide Stradella: Bleeding is an Unpleasant Complication in Endoscopy