Tetiana Lapikova-Bryhinska and Simon Kraler on the Role of JCAD in Post-ACS Adverse Events Prediction
Tetiana Lapikova-Bryhinska, Molecular Biology Researcher at UZH, reposted from Simon Kraler on LinkedIn:
”Exciting News!
I am honored to have been a co-author on our recently published study in the European Heart Journal, which explores the role of JCAD in predicting major adverse cardiovascular events following acute coronary syndrome (ACS).
A big thank you to Simon Kraler, Thomas F. Lรผscher, Giovanni G Camici, Alexander Akhmedov, and other colleagues for their collaboration and support throughout this important research.
Iโm excited to share our findings and look forward to future advancements in cardiology, as well as the potential of JCAD as a therapeutic target.
This publication, released just in time for Christmas, feels like a wonderful gift as we enter the New Year!
Read the full paper here”
Quoting Simon Kraler‘s post:
”Residual risk: is it time to move ๐๐๐ฒ๐จ๐ง๐ ๐๐๐-๐ ๐๐ง๐ ๐ข๐ง๐๐ฅ๐๐ฆ๐ฆ๐๐ญ๐ข๐จ๐ง?
Despite guideline-directed lipid lowering and anti-inflammatory therapy, patients with a recent ACS remain at ๐ฏ๐๐ซ๐ฒ ๐ก๐ข๐ ๐ก ๐ข๐ฌ๐๐ก๐๐๐ฆ๐ข๐ ๐ซ๐ข๐ฌ๐ค.
Based on GWAS and mechanistic data, we hypothesized that JCAD (‘๐unctional Protein Associated with ๐oronary ๐rtery ๐isease’) on chromosome 10 might represent the missing link.
In our newly published European Heart Journal study, JCAD independently predicted 1-๐ฒ๐๐๐ซ ๐๐๐๐ in patients with residual lipid risk, inflammatory risk, or both – notably ๐ข๐ง๐๐๐ฉ๐๐ง๐๐๐ง๐ญ ๐จ๐ ๐๐๐-๐ ๐๐ง๐ ๐ก๐ฌ-๐๐๐.
High JCAD equals impaired ๐๐ง๐๐จ๐ ๐๐ง๐จ๐ฎ๐ฌ ๐๐ข๐๐ซ๐ข๐ง๐จ๐ฅ๐ฒ๐ฌ๐ข๐ฌ and high MACE risk, with similar results obtained during external validation.
JCAD may represent a ๐ง๐จ๐ฏ๐๐ฅ ๐ญ๐ก๐๐ซ๐๐ฉ๐๐ฎ๐ญ๐ข๐ ๐ญ๐๐ซ๐ ๐๐ญ to address residual risk after a recent ACS.
Full paper.
Special thanks to the colleagues and friends at University of Genoa, King’s College London, University of Zurich, CHUV | Lausanne university hospital, Universitรคtsspital Zรผrich, HUG – Hopitaux Universitaires de Genรจve and Insel Gruppe.
Thank you Thomas F. Lรผscher, Luca Liberale, Giovanni G Camici, Diana Gorog Lorenz Rรคber, Davide Di Vece, Yifan Wang, Francesco Bruno and all!”
Read the full article here.
Article: The junctional protein associated with coronary artery disease predicts adverse cardiovascular events in patients with acute coronary syndromes at high residual risk
Authors: Simon Kraler , Luca Liberale , Amedeo Tirandi , Margherita Moriero , Yifan Wang , Mohamed Farag , Federico Carbone , Maria B Bertolotto , Valentina Pusterla , Davide Ramoni , Stefano Ministrini , Yustina M Puspitasari , Francesco Bruno , Lorenz Rรคber , Davide Di Vece , Christian Templin , Olivier Muller , Franรงois Mach , Filippo Crea , Giovanni G Camici , Tetiana Lapikova-Bryhinska , Alexander Akhmedov , Arnold von Eckardstein , Diana A Gorog , Fabrizio Montecucco , Thomas F Lรผscher
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