Alan Nurden Shares A Study on Unusual Form of Glanzmann Thrombasthenia
Alan Nurden, Emeritus Research Director at CNRS, shared on LinkedIn:
”A detailed review of published cases of an unusual form of Glanzmann thrombasthenia where gain-of-function mutations in ITGA2B/ITGB3 genes are linked to dysregulation of RhoA activity in megakaryocytes and cytoskeletal-mediated changes in proplatelet formation and platelet release.
Such cases offer a rare insight into integrin biology.”
Read the full article here.
Article: ITGA2B/ITGB3-Related Macrothrombocytopenia Associated With Gain-of-Function Mutations in ITGA2B or ITGB3 Genes
Authors: Jiao Wu, Han Yan, Zijian Li, Yilin Zhu, Ruonan Shao, Honglei Xin, Tongyu Jia, Mengyu Ge, Lu Zhang, Suyu Jiang, Jianhua Mao, Jiansong Huang, Chao Fang, Xiaodong Xi, Xiaofeng Shi
Stay updated on all scientific advances with Hemostasis Today.
-
Apr 19, 2026, 15:59Nour Al-Mozain: Why Stem Cell Collection Parameters Need Adjustment in SCD for Gene Therapy?
-
Apr 19, 2026, 15:42S. Kate Hartman: A Clinical Framework for Anemia, Bleeding, and Transfusion Decision-Making
-
Apr 19, 2026, 15:20CHAMPION-AF Demonstrated Better Freedom From Clinically Relevant Bleeding Events – Boston Scientific Cardiology
-
Apr 19, 2026, 14:37Jean-Jacques Mourad: Cohort Study Insights on Aspirin Use in Patients with Horton’s Disease
-
Apr 19, 2026, 14:36Francisco Ujueta: Pulmonary Embolism Care Doesn’t End at the Acute Phase
-
Apr 19, 2026, 14:35Flora Peyvandi: Marking the Beginning of a Future with Less Suffering on World Haemophilia Day
-
Apr 19, 2026, 14:34Chokri Ben Lamine: 50 High-Yield Pearls on Hemoglobin Cutoffs for Anaemia from WHO 2024 Guideline
-
Apr 19, 2026, 14:31Kate Iyore: Simple Explanation of Deep Vein Thrombosis and Pulmonary Embolism
-
Apr 19, 2026, 14:08Emily Smith: From Personal Experience to Global Advocacy on World Haemophilia Day