Peisong Ma on GRK5 Polymorphism Affecting Platelets
Peisong Ma, Associate Professor at Thomas Jefferson University, shared on LinkedIn:
”Excited to share that our latest manuscript, “Understanding how a highly prevalent GRK5 polymorphism affects platelets and enhances thrombotic risk,” is now published in the Blood Journal (online first).
In this study, we identify GRK5 as a previously unrecognized regulator of platelet PAR1 signaling and provide the first experimental evidence linking this common A→G variant to enhanced thrombin/PAR1 signaling and increased thrombus formation in vivo.
Using human GG donor platelets, iPSC-derived megakaryocytes, GRK5 inhibition, a humanized mouse model, and two preclinical models, our work connects human genetics → platelet GPCR regulation → thrombotic disease. These findings highlight GRK5 as a potential contributor to stroke and venous thromboembolism risk, with implications for future thrombophilia assessment.
Huge congratulations to my PhD students Yanki Yarman and Xuefei Zhao, and sincere thanks to our collaborators at Jefferson, CHOP, Cambridge, Mount Sinai, UPenn, and Purdue.”
Read the full article here.
Article: Understanding how a highly prevalent GRK5 polymorphism affects platelets and enhances thrombotic risk
Authors: Yanki Yarman, Xuefei Zhao, Hyunsook Ahn, Hannah A Thomson, Amrita Sarkar, Tian Yuan, Meghan E. Roberts, Jeremy Wurtzel, Scott L Diamond, John J.G Tesmer, Deborah L French, Maurizio Tomaiuolo, Ernest Turro, William Astle, Lawrence E. Goldfinger, Steven E. McKenzie, Jeffrey Benovic, Timothy J. Stalker, Mortimer Poncz, Peisong Ma
Stay updated on all scientific advances with Hemostasis Today.
-
Jun 29, 2026, 06:48Christina Pohlman: Anticoagulants and Bone Health – APS Awareness Month Day 23
-
Jun 29, 2026, 06:33Andreas Calatzis: Can Fibrinolysis Sensitivity Be Claimed Without a Reference Standard
-
Jun 29, 2026, 06:25Aliaa Albadri: When a Hair Wash Leads to a Stroke Workup
-
Jun 29, 2026, 06:22Tehreen Parveen: Historical Milestone in Drug Discovery – The Discovery of Aspirin
-
Jun 29, 2026, 06:16Muhammad Sufyan: Deep Vein Thrombosis – Recognizing the Warning Signs
-
Jun 29, 2026, 05:33Janak Sadhu: Uniting for The Stroke-Free Mehsana Initiative
-
Jun 29, 2026, 05:20Deepti Sachan: A Global Exchange Shaping the Future of Transfusion Medicine at ISBT 2026
-
Jun 29, 2026, 04:50Scott Cameron: ACC/AHA Guidance on Acute Pulmonary Embolism Management
-
Jun 29, 2026, 03:10Aryabhatta Sadhu: ABO and Rh Incompatibility In Stem Cell Transplantation