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Bryan Fry: First Evidence That Bothrops atrox Venom Directly Activates Human Factor VII
environment.uq.edu.au
Feb 23, 2026, 17:42

Bryan Fry: First Evidence That Bothrops atrox Venom Directly Activates Human Factor VII

Bryan Fry, Professor of Toxicology at the University of Queensland, shared a post on LinkedIn, about a recent article he and his colleagues co-authored, adding:

”Highlights

  • Neonate Bothrops atrox venom is far more procoagulant than adult venom on plasma and fibrinogen.
  • Neonate venom activates prothrombin and Factor VII via FVa-dependent pathways more strongly than adults.
  • We provide the first evidence that Bothrops atrox venom directly activates human Factor VII.
  • Clinically used antivenoms neutralise adult venom better than neonate venom; Butantan performs best.
  • Findings indicate high coagulopathy risk after neonate bites and support adding neonate venom to antivenom immunizing mixture.”

Title: Pirates of the coagulase: Clinical implications of dramatic ontogenetic shifts in Yellow Beard (Bothrops atrox) lancehead pitviper Factor Va-mediated venom activation of blood clotting factors

Authors: Katherine Jordan, Patrick S. Champagne, Lorenzo Seneci, Bryan G. Fry

Read the Full Article on Toxicon.

Bryan Fry

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Bothrops atrox Bryan Fry Clotting Activation coagulation Health Hematology Hemostasis Hemostasis Today Katherine Jordan Lorenzo Seneci Medicine Patrick S. Champagne Pitviper Venom thrombosis Toxicology Toxicon Yellow Beard
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