John Abraham։ The Role of Diagnostic Splenectomy in Unexplained Splenomegaly
John Abraham, Assistant Professor at Christian Medical College and Hospital, shared a post on LinkedIn about a recent article by Nutan Joshi et al, published in the Indian Journal of Hematology and Blood Transfusion։
”Diagnostic Splenectomy in 2026 – Still Relevant?
A large single-center series (123 cases) from CMC Vellore revisits its role in unexplained splenomegaly.
Key Points:
- Diagnostic yield: 72%
- Lymphoma diagnosed: 58.5%
– 66% B-cell NHL (mainly SMZL, DLBCL)
– 23% T-cell
– Subtyping possible in ~88%
Predictors? None.
Age, B symptoms, LDH, splenic size, focal lesions — not reliably predictive.
Risk: 30-day mortality ~5% (sepsis most common)
Even in the PET-CT era, diagnostic splenectomy retains value — but strictly as a last-line diagnostic intervention.”
Title: Diagnostic Splenectomy: Clinical Profile, Role and Relevance in the Diagnosis of Lymphoma
Authors: Nutan Joshi, Sujith Karumathil, Sushil Selvarajan, Kavitha M. Lakshmi, S. Elanthenral, Santhosh Raj, Abi Manesh, Divya Susanna Ninan, Junita John, Myla Jacob, D. K. Titus, Uday Kulkarni, Biju George, Aby Abraham, Vikram Mathews, Anu Korula
Read the Full Article on Indian Journal of Hematology and Blood Transfusion.
Stay updated on all scientific advances with Hemostasis Today.
-
Jul 21, 2026, 19:43Abdul Mannan: Why Is HbS or HbD Approximately 40% in Heterozygotes Rather Than 50%?
-
Jul 21, 2026, 19:42Haemophilia Maintains a 2025 Impact Factor of 3.0 – WFH
-
Jul 21, 2026, 19:41Wolfgang Miesbach: SR604 Restores Thrombin Generation Where It Is Needed
-
Jul 21, 2026, 19:40Filmon Tesfay: Our New Case Report on Cerebral Venous Thrombosis Is Now Published
-
Jul 21, 2026, 15:02Sham Zamil: The Role of ABO Compatibility in Platelet Pooling
-
Jul 21, 2026, 13:43Dima Shulkin: Assessing AI-Driven Blood Test Screening for Colorectal Cancer
-
Jul 21, 2026, 13:24Benoit Mores: National Initiative Targets Better Cardiovascular Outcomes
-
Jul 21, 2026, 13:10Paolo Zamboni: Chronic Cerebrospinal Venous Insufficiency Hypothesis in Multiple Sclerosis
-
Jul 21, 2026, 13:05Danai Poutakidou։ The Diagnostic Pitfalls of Unexpected PT/INR Prolongation