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Caitlin Raymond: Managing Crigler–Najjar Syndrome Type 1 Crisis Without a Standard TPE Protocol
Caitlin Raymond/LinkedIn
Mar 12, 2026, 17:06

Caitlin Raymond: Managing Crigler–Najjar Syndrome Type 1 Crisis Without a Standard TPE Protocol

Caitlin Raymond, Assistant Professor of Pathology and Transfusion Medicine at the University of Wisconsin-Madison, shared a post on LinkedIn:

“Sometimes the evidence just isn’t there.

I recently consulted on a young adult with Crigler-Najjar syndrome type 1 in acute crisis — bilirubin over 30, altered mental status, concern for acute-on-chronic kernicterus.

The team needed TPE. I needed a protocol.

Except there isn’t one.

Every case report I found treats plasmapheresis as a footnote.

No volumes.

No replacement fluid recommendations.

No schedule.

Nothing standardized.

So I made decisions based on pathophysiology, first principles, and the closest analogous literature I could find.

I wrote it all up – the case, the evidence gaps, and the reasoning – in a new blog post.

This is my ask to the apheresis and transfusion medicine community: if you’ve done TPE for Crigler-Najjar, share your experience.

We need to start building the evidence base, even if it begins with a conversation on LinkedIn.”

Caitlin Raymond: Managing Crigler–Najjar Syndrome Type 1 Crisis Without a Standard TPE Protocol

Other posts featuring Caitlin Raymond on Hemostasis Today.

Caitlin Raymond Crigler-Najjar syndrome Health Hematology Hemostasis News Hemostasis Today Medicine Therapeutic Plasma Exchange TPE
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