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Lorenz Räber: New Insights Into Silent Plaque Ruptures in AMI Patients
Lorenz Räber and Ryota Kakizaki
Mar 14, 2026, 15:37

Lorenz Räber: New Insights Into Silent Plaque Ruptures in AMI Patients

Lorenz Räber, Vice President of Swiss Society of Cardiology, shared a post on LinkedIn about a recent article he and his colleagues co-authored, adding:

“New publication European Heart Journal

In this study, we phenotyped lesions with silent plaque ruptures (PR) in non infarct related vessels of 336 AMI patients and found.

In larger plaque volume, positive remodeling, and thinner fibrous cap associated with rupture. Biomarkers (eg LDL-C, Lp(a), IFNy, interleukin-6; MMP-12; TNFa, hsCRP) were not correlated with multivessel plaque instability.

50% of plaques healed at 1 YR imaging with OCT.

All patients received high intensity statin therapy (at least), and the majority of healed plaques transformed into a fibrous morphology.

Although not powered for events, no excess in CV outcomes was noted in the PR group.

Great Editorial by Aloke Finn, Renu Virmani, CV Path Institute, Washington

Congratulations to the first author Ryota Kakizaki who spent a successful 3 YR fellowship at the Dep of Cardiology Insel Gruppe and we are proud on his persistence on this project published in the European Heart Journal this week.”

Title: Silent plaque ruptures in non-obstructive lesions of non–infarct-related arteries: a multimodality, serial intracoronary imaging study

Authors: Ryota Kakizaki, Flavio G Biccirè, Sylvain Losdat, Yasushi Ueki, Jonas D Häner, Hiroki Shibutani, Tatsuhiko Otsuka, Sarah Bär, Jacob Lønborg, Ernest Spitzer, George C M Siontis, Anna S Ondracek, Robert-Jan van Geuns, Yu-Jen Wang, Christian M Matter, Juan F Iglesias, David Spirk, Joost Daemen, Gregor Fahrni, Felix Mahfoud, Thomas Engstrøm, Irene M Lang, Konstantinos C Koskinas, Lorenz Räber

Read the Full Article on European Heart Journal

lorenz Räber

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Anna S Ondracek Christian M Matter David Spirk Ernest Spitzer Felix Mahfoud Flavio G Biccirè George C M Siontis Gregor Fahrni Health Hematology Hemostasis Hemostasis News Hemostasis Today Hiroki Shibutani hsCRP IFNy interleukin-6 Irene M. Lang Jacob Lønborg Jonas D Häner Joost Daemen Juan F. Iglesias Konstantinos C Koskinas LDL-C Lorenz Räber Lp(a) Medicine MMP-12 plaque rupture Robert-Jan van Geuns Ryota Kakizaki Sarah Bär Sylvain Losdat Tatsuhiko Otsuka Thomas Engstrøm TNFa Yasushi Ueki Yu-Jen Wang
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