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Timothy Glidewell: Genetic Signals of Platelet and Clotting Pathways in Cryptogenic Stroke
Timothy Glidewell/LinkedIn
Mar 13, 2026, 21:29

Timothy Glidewell: Genetic Signals of Platelet and Clotting Pathways in Cryptogenic Stroke

Timothy Glidewell, Spatial Regional Account Manager at Bruker Spatial, shared on LinkedIn about a recent article by Priya Dev et al, published in Plos Journal:

”Cryptogenic stroke is one of the toughest problems in medicine: patients have a stroke, but we can’t pin down the ‘why.’

This study looks for genetic clues in an understudied Indian cohort.

Using whole-exome sequencing on 16 patients and 16 unaffected relatives, the authors found 17 rare, potentially harmful variants across 15 known stroke-related genes.

When they grouped the signals, a clear theme popped out: platelet and clotting biology (think platelet activation and fibrin clot formation).

They also highlighted a small network of interacting candidates for follow-up.

Next step: validating these pathways in tissue.

GeoMx could help map RNA/protein signals in specific vascular or clot regions.”

Title: Short report: Targeted analysis of whole exome sequencing data in Indian cryptogenic stroke patients

Authors: Priya Dev, Jenefer M. Blackwell, Rajiv Kumar, Vijay Mishra, Abhishek Pathak

Read the Full Article on Plos Journal

Timothy Glidewell: Genetic Signals of Platelet and Clotting Pathways in Cryptogenic Stroke

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Abhishek Pathak Cryptogenic Stroke Health Hematology Hemostasis Hemostasis News Hemostasis Today Jenefer M. Blackwell Medicine Priya Dev Rajiv Kumar thrombosis Timothy Glidewell Vijay Mishra
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