Mar 21, 2026, 15:32
Marwa Mostafa: Iron Metabolism in the Differential Diagnosis of Anemia
Marwa Mostafa, Clinical Pathologist at Apollomed Medical Center, shared a post on LinkedIn:
“After classifying anemia by MCV and reticulocyte response…
The next question is:
- Is iron deficient, unavailable… or overloaded?
Understanding iron metabolism is the key.
Here’s a simple clinical approach
Iron deficiency anemia
- Decreased Serum iron
- Increased TIBC
- Decreased Ferritin
Anemia of chronic disease
- Decreased Serum iron
- Decreased / normal TIBC
- Increased Ferritin
Iron is present but not available (hepcidin effect)
Iron overload
- Increased Serum iron
- Decreased TIBC
- Increased Ferritin
Risk of iron deposition – liver, heart, endocrine organs
Clinical tip:
- Ferritin is a storage marker and an acute phase reactant
Always interpret it in clinical context
Understanding iron metabolism simplifies anemia interpretation and helps avoid common diagnostic pitfalls.
For more details you can visit․”
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