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Marwa Mostafa: Iron Metabolism in the Differential Diagnosis of Anemia
Mar 21, 2026, 15:32

Marwa Mostafa: Iron Metabolism in the Differential Diagnosis of Anemia

Marwa Mostafa, Clinical Pathologist at Apollomed Medical Center, shared a post on LinkedIn:

“After classifying anemia by MCV and reticulocyte response…

The next question is:

  • Is iron deficient, unavailable… or overloaded?

Understanding iron metabolism is the key.

Here’s a simple clinical approach 

Iron deficiency anemia

  • Decreased Serum iron
  • Increased TIBC
  • Decreased Ferritin

Anemia of chronic disease

  • Decreased Serum iron
  • Decreased / normal TIBC
  • Increased Ferritin

Iron is present but not available (hepcidin effect)

Iron overload

  • Increased Serum iron
  • Decreased TIBC
  • Increased Ferritin

Risk of iron deposition – liver, heart, endocrine organs

Clinical tip:

  • Ferritin is a storage marker and an acute phase reactant

Always interpret it in clinical context

Understanding iron metabolism simplifies anemia interpretation and helps avoid common diagnostic pitfalls.

For more details you can visit․”

Marwa Mostafa: Iron Metabolism in the Differential Diagnosis of Anemia

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