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Antiphospholipid Syndrome in Pregnancy – One of Hematology’s Most Complex Challenges – RPTH

RPTH/LinkedIn

Apr 6, 2026, 07:14

Antiphospholipid Syndrome in Pregnancy – One of Hematology’s Most Complex Challenges – RPTH

RPTH Journal shared a post on LinkedIn about a recent article by Andrew J. Doyle, adding:

“Antiphospholipid syndrome in pregnancy: one of hematology’s most complex challenges

Antiphospholipid syndrome (APS) is a multisystem autoimmune disorder that significantly raises the risk of blood clots and adverse pregnancy outcomes.

Diagnosing it is often difficult, treatment options remain limited – and pregnancy adds a whole new layer of complexity.

A state-of-the-art review in RPTH Journal based on a lecture presented at the International Society on Thrombosis and Haemostasis (ISTH) 2025 Congress, offers a hematologic perspective on APS management during pregnancy, including prepregnancy counseling and thrombosis-related issues.

Key takeaways:

APS carries high risks of thrombosis and late adverse pregnancy outcomes
Management relies on anticoagulation and close specialist monitoring
Risk stratification remains a major unmet need

Few novel treatments are on the horizon…

This review focuses primarily on late pregnancy complications and thrombotic issues rather than earlier events such as recurrent miscarriage, which fall more within the obstetric perspective.

More than 40 years after the initial description of APS by Graham Hughes, there is still much to improve, especially in personalizing treatment to enhance outcomes for pregnant patients.”

Oliver Tiebel, Medical Director, Laboratory Director MVZ at the Carl Gustav Carus University Hospital Dresden GmbH, reposted RPTH’s a post on LinkedIn:

“Very interesting paper … great compilation covering this extreme important issue … many thx to the authors Andrew Doyle, Catrin Cox and Karen Breen”

Title: Antiphospholipid syndrome and pregnancy – a hematologic perspective

Authors: Andrew J. Doyle, Catrin Cox, Karen A. Breen

Read the Full Article on RPTH RPTH