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A Self-Regulatory Mechanism of The PolyP-Thrombin-Fibrin Complex – JTH
Authors of the article - Xintong Yao/LinkedIn, James C. Fredenburgh/ISTH, Jeffrey I. Weitz/McMaster University
Apr 11, 2026, 12:29

A Self-Regulatory Mechanism of The PolyP-Thrombin-Fibrin Complex – JTH

Journal of Thrombosis and Haemostasis (JTH) shared a post on LinkedIn about a recent article by Xintong Yao et al, adding:

”Formation of a Ternary Polyphosphate-Thrombin-Fibrin Complex Attenuates Thrombin Activity

Platelet-released polyphosphate, like heparin, promotes formation of a ternary polyP-thrombin-fibrin complex that simultaneously protects clot-bound thrombin from antithrombin inhibition while reducing its capacity to generate new fibrin, revealing a novel self-regulatory mechanism in coagulation.”

Title: Formation of a ternary polyphosphate-thrombin-fibrin complex attenuates thrombin activity

Authors: Xintong Yao, James C. Fredenburgh, Jeffrey I. Weitz

Read the Full Article on JTH

A Self-Regulatory Mechanism of The PolyP-Thrombin-Fibrin Complex - JTH

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Fibrin Health Hematology Hemostasis Hemostasis News Hemostasis Today Heparin James C. Fredenburgh Jeffrey I. Weitz JTH Medicine Platelet PLP Polyphosphate Thrombin thrombosis Xintong Yao
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