Paul Watton: How Immune Stress Affects Metabolism and Epigenetics in CD8+ T Cells
Paul Watton, Independent Researcher, shared a post on LinkedIn about a recent article by Yangtao Shangguan et al., published in the Trends in Endocrinology and Metabolism:
”Whilst this is not an ME/cfs study, it nevertheless provides a coherent framework in which persistent immune stress, mitochondrial dysfunction, metabolic inflexibility and epigenetic remodelling are not separate phenomena, but parts of a single self-reinforcing network within CD8+ T cells.
It further indicates that abnormalities in amino‑acid handling may do more than signal nutritional or energetic stress; they can directly influence the epigenetic mechanisms that sustain immune‑cell identity and activity.”
Title: CD8+ T cell stressors converge on shared metabolic–epigenetic networks
Authors: Yangtao Shangguan, Jianxiang Wang, Ping-Chih Ho, Yingxi Xu
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