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Jim Hoffman: Targeting NETosis and Microclotting to Restore Immune and Hemostatic Balance
Jim Hoffman/LinkedIn; Ronald Li/LinkedIn
Apr 21, 2026, 09:15

Jim Hoffman: Targeting NETosis and Microclotting to Restore Immune and Hemostatic Balance

Jim Hoffman, Former Technical Advisor at Cygnus Technologies, LLC, shared Ronald Li’s post on LinkedIn, adding:

“Very interesting and informative in vitro studies.

You may want to investigate this further with Resia Pretorius and the PolyBio team who are looking for better treatment of microclotting, post infection Illnesses, including Long COVID PASC.

Perhaps desulfated-heparin analogs could help better mitigate the development of severe life-threatening NETosis dysregulation and circulatory decline, if tried in vivo.

However, I still prefer trying NETs/extracellular chromatin/histone removal from the blood using these emerging extracorporeal blood purification treatments for patients at high-risk of refractory SIRS and development of life-threatening sepsis/DIC.

Based on the largely failed clinical performance of systemically administered Activated Protein C, I have long believed the depletion of circulating charged histones and other extracellular chromatin debris that aggregates cells, rather than drug neutralization of histones, provides the greatest opportunity for restoring immune system homeostasis and improving blood hemostasis in response to infection and other triggers of worsening NETosis dysregulation.”

Ronald Li, Associate Professor in Emergency and Critical Care at North Carolina State University, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Frontiers in Veterinary Science:

“Congratulations Dr. Maria Andrea Guzman Solano on this publication.

As a member of the graduating class of the Veterinary Academic Leadership Fellow program at NC State College of Veterinary Medicine, she successfully advanced her research idea from conception through execution to publication.

I am excited to see her continue this research path as she takes on a new role as Associate Professor of Emergency and Critical Care at the University of Missouri.”

Title: Non-anticoagulant heparin attenuates histone-mediated platelet–leukocyte aggregation and neutrophil extracellular trap formation in a canine whole blood model

Authors: Maria A. Guzmán, Lunden Simpson, Ronald H. L. Li

Jim Hoffman: Targeting NETosis and Microclotting to Restore Immune and Hemostatic Balance

Other posts featuring Jim Hoffman on Hemostasis Today.

activated protein C bleeding disorders Frontiers in Veterinary Science Health Hematology Hemostasis Hemostasis News Hemostasis Today Immune System immune system homeostasis Jim Hoffman Lunden Simpson Maria A. Guzmán Medicine NC State College of Veterinary Medicine Netosis NETosis dysregulation NETs Ronald H. L. Li Ronald Li Veterinary Academic Leadership Fellow program
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