Tushar Pandey: When Low Platelets Are Not ITP
Tushar Pandey, Director and Head of Raghav Institute of Hematology, Hemato-Oncology and BMT at Raghav Healthcare, Editorial Board Member at Journal of Cancer Chemotherapy, Program Director of Hemato – Oncology at International Association For Integrated Oncology, shared a post on LinkedIn:
”When to suspect ITP, TTP, HIT and VITT – a clinical priority
Thrombocytopenia is common…
But not all low platelets are ITP.
Early recognition can be life-saving.
Think beyond ITP
ITP (Immune Thrombocytopenia)
- Isolated low platelets
- Mucocutaneous bleeding
- Normal Hb and WBC
TTP (Thrombotic Thrombocytopenic Purpura)
- Thrombocytopenia plus MAHA
- Neurological symptoms
- Renal involvement
Hematological emergency
HIT (Heparin Induced Thrombocytopenia)
- Platelet fall more than 50%
- 5–14 days after heparin
- Thrombosis present
VITT (Vaccine Induced Thrombotic Thrombocytopenia)
- 5–30 days post vaccination
- Unusual thrombosis (CVST, splanchnic)
- High D-dimer
Key takeaway
Low platelets are not all the same
Missing these diagnoses can be fatal
Clinical rule
Thrombocytopenia plus
- Hemolysis
- Thrombosis
- Neurologic symptoms
- Drug / vaccine history
Think TTP / HIT / VITT
Hematologist should be consulted whenever such suspicions arise
Early suspicion. Timely diagnosis. Right decision – Saves lives.”
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