Hemostasis Today

Neema Ngugi: Understanding the D-Dimer Test – A Key Tool in Detecting Blood Clots
Apr 30, 2026, 14:52

Neema Ngugi: Understanding the D-Dimer Test – A Key Tool in Detecting Blood Clots

Neema Ngugi, Nephrology Nurse Nephrology of The Nairobi South Hospital, shared a post on LinkedIn:

“Understanding the D-Dimer Test: A Key Tool in Detecting Blood Clots

The D-Dimer test plays a crucial role in clinical decision-making, especially when evaluating patients for suspected thrombotic events.

It measures fibrin degradation products – essentially fragments produced when a blood clot dissolves in the body.

Why is it done?

Primarily, the D-Dimer test is used to rule out serious clotting conditions such as:

  • Deep Vein Thrombosis (DVT)
  • Pulmonary Embolism (PE)
  • Disseminated Intravascular Coagulation (DIC)
  • Stroke or Myocardial Infarction

How to interpret results?

  • Normal D-Dimer – Clotting is unlikely
  • Elevated D-Dimer – Not diagnostic, but signals the need for further investigation (e.g., imaging studies)

Important to remember:

An elevated D-Dimer is not specific.

Levels can also rise in conditions such as:

  • Infection
  • Pregnancy
  • Recent surgery
  • Liver disease
  • Cancer

Clinical takeaway:

The D-Dimer test is most powerful when used appropriately – especially in low to moderate-risk patients – to safely exclude life-threatening clotting conditions and avoid unnecessary imaging.

As healthcare professionals, understanding when and how to use this test ensures accurate diagnosis, timely intervention, and improved patient outcomes.”

Neema Ngugi

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