Vitamin C Testing May Be Worth Considering In BDUC- RPTH Journal
RPTH Journal shared a post on LinkedIn about a recent article by Florian Winkler et al., published in RPTH Journal, adding:
“Bruising, anaemia, and skin changes:could the answer be as simple as vitamin C deficency?
When a patient presents with bleeding symptoms but all haemostatic tests come back normal, the label ‘bleeding disorder of unknown cause’ (BDUC) is often applied.
But could a nutritional deficiency be hiding in plain sight?
A new case report in RPTH Journal describes a 26-year-old man presenting with extensive ecchymoses, anaemia, and sclerodermatous skin changes of the left leg, with entirely normal haemostatic workup.
Key details:
- Nutritional history revealed markedly restricted eating habits
- Severe vitamin C deficiency was identified as the underlying cause
- Vitamin C supplementation led to normalisation of haemoglobin and marked improvement of skin changes
- No haematologic or dermatologic treatment was required
This case is a timely reminder that not all bleeding disorders are haematologic in origin, and that a simple nutritional deficiency can convincingly mimic both haematologic and dermatologic conditions.
In selected BDUC patients, vitamin C testing may be worth considering.”
Title: Unexplained bleeding tendency and scleroderma-like skin changes: a diagnostic journey to vitamin C deficiency
Authors: Florian Winkler, Peter Maximilian Heil, Johannes Thaler, Wolfgang R. Sperr, Cihan Ay, Johanna Strobl, Johanna Gebhart, Dino Mehic
Other articles about RPTH Journal on Hemostasis Today.
-
Aug 4, 2026, 21:28New Frontiers in Platelet Biology – BJHaem
-
Aug 4, 2026, 20:48New Real-World Data on Efanesoctocog Alfa From France – CRH French Reference Center for Hemophilia Lyon
-
Aug 4, 2026, 20:37Hisam Siddiqi: Haemoglobinopathy Basics – A Quick Guide to Thalassaemia
-
Aug 4, 2026, 20:36Ifeanyichukwu Ifechidere: AI May Soon Interpret Coagulation Results Better Than Some Healthcare Professionals
-
Aug 4, 2026, 20:35Ediga Naga Pradeep Kumar: Excited to Share My Latest Data Analytics Project – Stroke Risk Analysis Dashboard
-
Aug 4, 2026, 20:34Amar Shah: Improving Thrombolysis for Acute Stroke Through Quality Improvement
-
Aug 4, 2026, 20:33Federica Sepe: Are Biomarkers Finally Ready for Precision Stroke Medicine?
-
Aug 4, 2026, 20:10Kabir Olaniran: Sickle Cell Trait and Chronic Kidney Disease Risk
-
Aug 4, 2026, 19:57Toby Richards: Iron Deficiency Beyond Anaemia in Female Triathletes