Ajay Samkaria: Is Reliance on Weak D Testing Sufficient in Modern Transfusion Practice?
Ajay Samkaria, Product and Application Manager at Diagast Transfusion Medicine, shared a post on LinkedIn:
“Is reliance on Weak D testing sufficient in modern transfusion practice?
While preventing anti-D alloimmunization remains critical, it does not address clinically significant antibodies against other Rh antigens such as C and E.
Without extended Rh phenotyping, we risk missing these antigens – potentially leading to alloimmunization and hemolytic disease of the fetus and newborn in future pregnancies.
- Time to think beyond the D antigen.
- Comprehensive Rh phenotyping should be part of routine practice, especially in females of childbearing age.
Weak D testing addresses D antigen variability but fails to identify sensitization risks from other Rh antigens such as C and E. Undetected exposure may result in clinically significant alloantibodies, contributing to hemolytic disease of the fetus and newborn.
Extended Rh phenotyping (C, c, E, e) and antibody screening are essential strategies to improve maternal and fetal outcomes.”
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