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Could Albuminuria Be an Overlooked Marker of Thrombotic Risk? – RPTH Journal
RPTH Journal/LinkedIn
May 7, 2026, 07:48

Could Albuminuria Be an Overlooked Marker of Thrombotic Risk? – RPTH Journal

RPTH Journal shared a post on LinkedIn about a recent article by Xiu Hong Yang et al, adding:

”Could albuminuria be an overlooked marker of thrombotic risk?

We usually think of the urine albumin-to-creatinine ratio (UACR) as a kidney or cardiovascular marker.

But what if it also reflects systemic thrombotic vulnerability?

A new prospective RPTH study of 419,282 UK Biobank participants examined the relationship between albuminuria and future arterial thromboembolism (ATE) and pulmonary embolism (PE).

Here’s the key signal:

  • Moderate albuminuria (UACR 3–30 mg/mmol) increased ATE risk
  • Severe albuminuria (>30 mg/mmol) increased the risk of both ATE and c
  • Risk intensified further with reduced kidney function or low serum albumin

What’s changing under the hood:

  • Albuminuria reflects endothelial dysfunction and vascular injury
  • Associated with platelet activation and hypercoagulability
  • Linked to inflammatory pathways (CRP, VWF, ADAMTS13)
  • Suggests a systemic prothrombotic state – not just kidney disease

(Figures 1–3 show dose-dependent increases in thrombotic risk with rising UACR)

Translation:

Albuminuria may not simply mark renal injury; it may identify patients with heightened endothelial and thrombotic dysfunction.

Big questions for the field:

  • Should UACR be incorporated into thrombosis risk assessment?
  • Is albuminuria a mediator of thrombosis – or a marker of systemic vascular injury?
  • Could aggressive treatment of albuminuria reduce thromboembolic events?”

Title: Urine albumin-to-creatinine ratio and risks of incident arterial thromboembolism and pulmonary embolism among adults—a prospective cohort study

Authors: Xiu Hong Yang, Yao Liu, Zhen Xing Zhang, Yi Jun Lu, Chen Sheng Fu, Hui Min Jin, Zhi Bin Ye, Xiao Li Zhang

Could Albuminuria Be an Overlooked Marker of Thrombotic Risk? - RPTH Journal

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Albuminuria ATE Chen Sheng Fu Health Hematology Hemostasis Hemostasis News Hemostasis Today Hui Min Jin Medicine PE RPTH Journal thrombosis UACR Xiao Li Zhang Xiu Hong Yang Yao Liu Yi Jun Lu Zhen Xing Zhang Zhi Bin Ye
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