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Grigoris Gerotziafas: The Evolving Landscape of Genetic Risk Assessment in VTE
Grigoris Gerotziafas/LinkedIn
May 9, 2026, 14:10

Grigoris Gerotziafas: The Evolving Landscape of Genetic Risk Assessment in VTE

Grigoris Gerotziafas, Director of the Cancer, Vessels, Biology, and Therapeutics (CaVITE) Research Department, Head of the CRSA at Sorbonne University, shared on LinkedIn about a recent article he and his colleagues co-authored, published in Polish Archives of Internal Medicine, adding:

”The VAS Group is pleased to announce the publication of our latest review article in the Polish Archives of Internal Medicine (PAIM):
‘Inherited thrombophilia and polygenic risk scores in venous thromboembolism: from classical testing to genomic risk prediction’

This is an updated overview of the evolving landscape of genetic risk assessment in venous thromboembolism (VTE), moving from conventional inherited thrombophilia testing toward next-generation genomic and polygenic risk prediction approaches.

Key messages of the review include:

  • The complex interaction between genetic, acquired, and environmental determinants of VTE
  • The current and future role of classical thrombophilia testing (Factor V Leiden, Prothrombin G20210A, antithrombin, protein C and protein S deficiencies)
  • The emergence of genome-wide association studies (GWAS)-derived polygenic risk scores as innovative tools for individualized VTE risk stratification
  • The potential integration of genomic medicine into precision thrombosis prevention and management
  • The major scientific and clinical barriers that still limit implementation in routine clinical practice

This publication highlights the growing importance of precision medicine and translational vascular science in the management of thrombotic disease.

Congratulations and sincere thanks to all co-authors and collaborators for this excellent international collaborative work.”

Title: Inherited thrombophilia and polygenic risk scores in venous thromboembolism: from classical testing to genomic risk prediction

Authors: Benilde Cosmi, Grigoris Gerotziafas, Peter Marschang, Matija Kozak, Mariella Catalano, Agata Stanek

Grigoris Gerotziafas: The Evolving Landscape of Genetic Risk Assessment in VTE

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Agata Stanek Benilde Cosmi DVT Grigoris Gerotziafas GWAS Health Hematology Hemostasis Hemostasis News Hemostasis Today Leiden Mariella Catalano Matija Kozak Medicine PAIM Peter Marschang Polish Archives of Internal Medicine thromboembolism Thrombophilia thrombosis VTE
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