The Inflammasome Pathway as a Key Positive Regulator of HIT Pathology – JTH
Journal of Thrombosis and Haemostasis (JTH) shared on LinkedIn about a recent article by James Michael et al, adding:
”Heparin-Induced Thrombocytopenia Immune Complexes Activate the Inflammasome Pathway in a Complement-Dependent Manner
This study demonstrates that HIT immune complexes trigger NLRP3 inflammasome activation and IL-1β secretion via FcγRIIA and complement-dependent signaling in both human blood and transgenic mouse models, identifying the inflammasome pathway as a key positive regulator of HIT pathology. ”
Title: Heparin-induced thrombocytopenia immune complexes activate the inflammasome pathway in a complement-dependent manner
Authors: James Michael, Sanjay Khandelwal, Antonios Tawk, MD, MSc, Sophia Lazar, Christopher Garren Hester, Trenton G. Hiatt, Gowthami M. Arepally, Steven McKenzie
Stay updated on all scientific advances with Hemostasis Today.
-
May 12, 2026, 16:46Tagreed Alkaltham: Why Apheresis Matters in Modern Transfusion Medicine
-
May 12, 2026, 16:37Reinhold Kreutz: Cardiovascular Burden in Acute Intermittent Porphyria Needs Greater Awareness
-
May 12, 2026, 16:33Pablo Corral: The Truth About Very Low LDL-Cholesterol
-
May 12, 2026, 16:24Mildred Lundgren: We Must Talk About the Invisible Causes of Stroke
-
May 12, 2026, 16:17Irene Scala: The Sex Disparities In Access to Acute Stroke Treatments In Italy
-
May 12, 2026, 16:04May Nour: UCLA Health Mobile Stroke Unit Becomes The 1st In The World to Perform mCTA In the Field
-
May 12, 2026, 15:57Leonardo Roever: Prognostic Impact of Lipoprotein(a) and CAR in Elderly Acute Ischemic Stroke Patients
-
May 12, 2026, 15:54Bruno Pougault: Prioritizing Laboratory Tests in Resource-Limited Emergency Care
-
May 12, 2026, 15:37Jennifer Holter Chakrabarty: Supporting the Next Generation of Hematology Researchers