The Inflammasome Pathway as a Key Positive Regulator of HIT Pathology – JTH
Journal of Thrombosis and Haemostasis (JTH) shared on LinkedIn about a recent article by James Michael et al, adding:
”Heparin-Induced Thrombocytopenia Immune Complexes Activate the Inflammasome Pathway in a Complement-Dependent Manner
This study demonstrates that HIT immune complexes trigger NLRP3 inflammasome activation and IL-1β secretion via FcγRIIA and complement-dependent signaling in both human blood and transgenic mouse models, identifying the inflammasome pathway as a key positive regulator of HIT pathology. ”
Title: Heparin-induced thrombocytopenia immune complexes activate the inflammasome pathway in a complement-dependent manner
Authors: James Michael, Sanjay Khandelwal, Antonios Tawk, MD, MSc, Sophia Lazar, Christopher Garren Hester, Trenton G. Hiatt, Gowthami M. Arepally, Steven McKenzie
Stay updated on all scientific advances with Hemostasis Today.
-
Sep 30, 2026, 01:52Javed Anees: DADA2 – When a Young Stroke Is More Than a Stroke
-
Sep 30, 2026, 01:51How a Venous Thrombus Becomes Revascularized – ISTH
-
Sep 29, 2026, 22:45Victor Agunyego: Paracetamol – The Most Common Drug We Underestimate
-
Sep 29, 2026, 22:42Nova Sinclair: Advancing the Future of Hematology – Meet Our 2027 Organizing Committee
-
Sep 29, 2026, 22:41Lorenz Räber: Intracoronary Imaging in PCI – Why, When, How, and Which Modality?
-
Sep 29, 2026, 22:31Selma Turkovic: Pleased to Deliver the Opening Presentation at Kingston Hospital
-
Sep 29, 2026, 22:31Miguel Teran: Ultrasound and Simulation in Arterial Blood Sampling
-
Sep 29, 2026, 22:28Mohammad Refaei: Navigating Your Career in Hematology From Training to Practice
-
Sep 29, 2026, 22:27Matteo Foschi: 10 Clinical Pearls for Antithrombotic Therapy in Secondary Stroke Prevention