Sergio Emanuel Kaiser: A Whole New Array of Potent Oral PCSK9 Inhibitors
Sergio Emanuel Kaiser, Coordinator at UERJ – Discipline of Clinical and Experimental Pathophysiology, Associate Professor of Medicine at Rio de Janeiro State University, shared a post on LinkedIn about a recent article by Rick B. Vega, published in Circulation, adding:
“Exciting!
A whole new array of potent oral PCSK9 inhibitors is underway!
An 80% reduction of LDLc with the highest dose when associated with rosuvastatin 20 mg!”
Title: Laroprovstat, the First Oral Small-Molecule PCSK9 Inhibitor for the Treatment of Hypercholesterolemia: Results From a Randomized, Single-Blind, Placebo-Controlled Phase 1 Trial in Treatment-Naive Patients
Authors: Rick B. Vega, Gavin O’Mahony, April M. Barbour, Hongtao Yu, Jane Knöchel, Johan Brengdahl, Thomas Hochdörfer, Linnéa Bergenholm, Eva Töppner Carlsson, Andrea Ahnmark, Christina Rye Underwood, Anna Rudvik, Debra Carter, Johanna Laru, Aspen Gutgsell, Lee Twaddle, Pavlo Garkaviy, Anna Bogstedt, Eva Hurt-Camejo, Tasso Miliotis, Maria Ryaboshapkina, Andrease Hober, Brian Hubbard, Michael Serrano-Wu, Virendar Kaushik, Stefan Geschwindner, Michael C. McCarthy, Daniel Lindén, Jaya B. Rosenmeier
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