Alexandros Makis: 20-year Cohort of 112 Children with Autoimmune Neutropenia
Alexandros Makis, Professor of Pediatrics/Pediatric Hematology at Faculty of Medicine, School of Health Sciences, University of Ioannina, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in British Journal of Haematology, adding:
“I am pleased to share our latest publication in the British Journal of Haematology.
In a 20-year cohort of 112 children with autoimmune neutropenia, we confirmed that it isn’t one condition — it’s three distinct phenotypes with very different paths: Primary autoimmune neutropenia — benign, resolving in nearly 19 months despite very low neutrophil counts.
Long-lasting neutropenia — strong familial autoimmunity, delayed resolution (nearly 67 months).
Late-onset neutropenia — multi-lineage lymphopenia, frequent ANA positivity and associated autoimmune disease, yet no severe infection-related hospitalisations.
A paradox explained by preserved humoral immunity.
These findings support phenotype-based stratification as a tool for improving clinical monitoring and management of childhood autoimmune neutropenia.
Grateful to my co-authors Ioanna Saougou, Chrysoula Kosmeri, Nikolaos Chaliasos, Irene Mavroudi and Charalampos Pontikoglou and to the families whose long-term follow-up made this work possible.”
Title: Phenotype-specific immune profiles and outcomes in childhood autoimmune neutropenia: A 20-year cohort study
Authors: Ioanna Saougou, Chrysoula Kosmeri, Nikolaos Chaliasos, Irene Mavroudi, Charalampos Pontikoglou, Alexandros Makis
Stay updated on all scientific advances with Hemostasis Today.
-
Sep 29, 2026, 22:41Lorenz Räber: Intracoronary Imaging in PCI – Why, When, How, and Which Modality?
-
Sep 29, 2026, 22:31Selma Turkovic: Pleased to Deliver the Opening Presentation at Kingston Hospital
-
Sep 29, 2026, 22:31Miguel Teran: Ultrasound and Simulation in Arterial Blood Sampling
-
Sep 29, 2026, 21:47Javed Anees: DADA2 – When a Young Stroke Is More Than a Stroke
-
Sep 29, 2026, 22:28Mohammad Refaei: Navigating Your Career in Hematology From Training to Practice
-
Sep 29, 2026, 22:27Matteo Foschi: 10 Clinical Pearls for Antithrombotic Therapy in Secondary Stroke Prevention
-
Sep 29, 2026, 22:26A Global Call for Action on Cardiovascular Health on World Heart Day – ISTH
-
Sep 29, 2026, 19:00Caitlin Raymond: Can Artificial Blood Solve Blood Supply Shortages?
-
Sep 29, 2026, 18:51Chaza Alaji: Dyslipidemia, Thrombosis and the DIC Diagnostic Trap