Alfadil Haroon/Photo: researchgate.net
Jun 13, 2026, 08:50
Alfadil Haroon: Decoding the Complexity of Factor II Deficiency at EHA 2026
Alfadil Haroon, Assistant Consultant of Hematology at King Faisal Specialist Hospital and Research Centre, Assistant Professor at Alfaisal University, shared on LinkedIn:
”Decoding the complexity of factor II deficiency: new insights from EHA 2026
Factor II (prothrombin) deficiency is rare, but its clinical impact is profound. Our latest retrospective analysis of 106 patients reveals critical distinctions between congenital and acquired forms:
- Acquired FII Deficiency: Often presents later (median age 34) and is highly associated with autoimmune diseases and malignancy. Notably, 30.8% of these patients experience thrombotic events -strongly linked to autoimmune comorbidities (OR 5.43).
- Congenital FII Deficiency: Typically diagnosed much earlier (median age 16) with a significantly higher lifetime bleeding burden. Interestingly, we found no strong correlation between FII activity levels and bleeding severity, highlighting the need for individualized clinical assessment over lab values alone.
These findings underscore that Factor II deficiency isn’t just a bleeding disorder -it’s a complex balancing act between hemorrhage and thrombosis.”
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