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Alessandro Lucchesi: Mechanistic Biology as the Engine of Next-Generation Therapies
Alessandro Lucchesi/sohoitaly.com
Jun 17, 2026, 11:37

Alessandro Lucchesi: Mechanistic Biology as the Engine of Next-Generation Therapies

Alessandro Lucchesi, Consultant Hematologist at Romagna Scientific Institute for the Study and Treatment of Cancer (I.R.S.T.) Ltd., shared a post on LinkedIn:

“Stockholm, EHA 2026.

The biological foundations underpinning new therapies are, to my mind, of the utmost importance: to construct paradigms is to alter trajectories, and to look beyond appearances.

It is not only the clone that matters in myelofibrosis, just as it is not only the antibodies in ITP and wAIHA.

Inflammation as a primary driver of chronic disease, the dysregulation of tolerance, and dysfunctional cellular metabolism have long been at the centre of my work – and they are precisely what allow us to read mechanisms like XPO-1 dependence, or BTK as an integrator of immune activation, not as isolated targets but as expressions of a deeper biology.

I am grateful to Menarini Stemline and Sanofi for the platform to develop these arguments at the MF and ITP/wAIHA symposia, and to IRCCS Istituto Romagnolo per lo Studio dei Tumori ‘Dino Amadori’ – IRST Srl for the scientific home that makes such work possible.

The foundations are where the next therapies will be decided. That is the conversation I want to keep having.

Disclosure: invited speaker at the Menarini Stemline and Sanofi satellite symposia referenced here.”

Alessandro Lucchesi: Mechanistic Biology as the Engine of Next-Generation Therapies

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