Dinesh Viruvanti/LinkedIn
Jun 19, 2026, 09:05
Dinesh Viruvanti: Ineffective Erythropoiesis is not Just ‘Reduced RBC Production’
Dinesh Viruvanti, Pediatric Hematologist and Oncologist at Yashoda Hospitals, shared a post on LinkedIn:
“Ineffective erythropoiesis is not just ‘reduced RBC production’.
It is a high – effort marrow state with poor effective RBC output – often due to intramedullary hemolysis.
This distinction is clinically useful:
Peripheral hemolysis usually gives a good reticulocyte response, while ineffective erythropoiesis gives anemia with biochemical hemolysis but an inadequate reticulocyte response.
A concept worth revisiting in children with thalassemia, megaloblastic anemia, congenital dyserythropoietic anemia, sideroblastic anemia, and marrow disorders.”
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