Abdul Mannan: Pregnancy Changes Almost Every Coagulation Test
Abdul Mannan, Consultant Haematologist at Betsi Cadwaladr University Health Board, shared a post on LinkedIn:
“Pregnancy Changes Almost Every Coagulation Test
Pregnancy is nature’s largest coagulation experiment.
As gestation progresses:
- High Factor VIII
- High Von Willebrand factor
- High Fibrinogen
- High D-dimer
- Low Protein S activity
- Low Antithrombin
- Low Factor XIII
The result is a physiological hypercoagulable state.
Why it matters at the bench and the bedside:
D-dimer rises through pregnancy, so it becomes unreliable for excluding VTE Protein S falls, so testing for protein S deficiency in pregnancy is not reliable
Thrombosis risk climbs
Mild bleeding disorders can look temporarily corrected
There is a practical consequence here.
Most of these changes take 6 to 7 weeks postpartum to settle, and some variables can take up to 12 weeks.
That is why haematologists usually wait at least 12 weeks postpartum before using lab tests to exclude conditions like von Willebrand disease.
Normal pregnancy is not normal haemostasis.”
More posts featuring Abdul Mannan on Hemostasis Today.
-
Jun 20, 2026, 19:51Sushmita Sen: How are We Doing in Global Clinical Trials and Precision Hematology?
-
Jun 20, 2026, 19:46Rainer Kaiser: How Neutrophils Stiffen Thrombi in Acute Ischemic Stroke
-
Jun 20, 2026, 19:38Muhammad Amjad Sohail: Stroke – Recognize the Signs, Save a Life
-
Jun 20, 2026, 19:36Osman Eladani: How Do We Optimize Bleeding Risk Management in Elective Surgery?
-
Jun 20, 2026, 19:24Rubi Stephani Hellwege: Why Two Patients With the Same Cardiac Output Can Be Completely Different
-
Jun 20, 2026, 19:20Alexander Cohen: How Long Should You Treat VTE?
-
Jun 20, 2026, 19:17Michael Braun: The Work Is Not Finished in Sickle Cell Disease
-
Jun 20, 2026, 19:11Ayesha Masood: Delighted to Share My First Published Meta-Analysis
-
Jun 20, 2026, 18:56Registration Closing Tonight – 3rd Antithrombotic Stewardship Summit at ISTH 2026 – Anticoagulation Forum