Roberta Gualtierotti: Point-of-Care SPR Device for Rapid Detection of Anti-PEG Antibodies
Roberta Gualtierotti, Associate Professor of Internal Medicine at the University of Milan, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in scientific reports, nature, adding:
“Excited to share this new work on a point-of-care SPR device for rapid detection of anti-PEG antibodies by Laura Pasquardini et al
PEGylation is widely used in biologic drugs, including extended half-life FVIII products for hemophilia A, to improve safety and efficacy.
However, PEG itself may trigger anti-PEG antibodies, potentially causing loss of treatment efficacy.
Our study presents a portable, low-cost platform capable of detecting anti-PEG IgG and IgM in just 15 minutes from human plasma, with nanomolar sensitivity and strong agreement with other methods (SPR and ELISA).
A step forward toward personalized monitoring of PEG immunogenicity and safer use of PEGylated therapies.”
Title: Development of a portable device for the detection of anti-PEG antibodies in human plasma
Authors: Laura Pasquardini, Nunzio Cennamo, Camilla Rossi, Roberto Canteri, Lia Vanzetti, Marten Beeg, Roberta Gualtierotti, Luca Pasquale Renzullo, Ines Tavoletta, Lucia Schiavone, Carla Valsecchi, Chiara Suffritti, Flora Peyvandi, Marco Gobbi, Luigi Zeni
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