Nicolò Vianini: New Evidence Confirms Bone Marrow as the Primary Site of Thrombopoiesis
Nicolò Vianini, Resident Physician at the University Hospital of Verona, shared a post on LinkedIn about a recent article by Nathan L Asquith et al, published in Blood, adding:
“Megakaryocytes (MKs) generate thousands of platelets over their lifespan.
The roles of platelets in infection and inflammation has guided an interest to the study of extramedullary thrombopoiesis and therefore MKs have been increasingly reported within the spleen and lung.
However, the relative abundance of MKs in these organs compared to the bone marrow and the scale of their contribution to the platelet pool in a steady state remain controversial.
In the image is shown the contribution of bone marrow versus extramedullary megakaryocytes to platelet production.”
Title: The bone marrow is the primary site of thrombopoiesis
Authors: Nathan L Asquith, Estelle Carminita, Virginia Camacho, Antonio Rodriguez-Romera, David Stegner, Daniela Freire, Isabelle C Becker, Kellie R Machlus, Abdullah O Khan, Joseph E Italiano
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