Marcin Krzysztof Maniak: Linking Tissue Mechanics to Inflammation in Health and Disease
Marcin Krzysztof Maniak, Postgraduate Researcher at Edinburgh Medical School, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Journal of Experimental Medicine, adding:
“I’m excited to share that our Review article, ‘Mechanobiology of inflammation: Pulling the strings of innate immunity’, has now been published in the Journal of Experimental Medicine!
Inflammation is often thought of as a biochemical process, but it is also deeply physical. Every step we take, every breath, and every heartbeat generate mechanical forces that continuously shape how our immune cells behave.
We therefore propose mechanoinflammation as a unifying framework linking tissue mechanics to immune regulation in health and disease, while also highlighting translational opportunities for diagnostics and therapy.
Critically, chronic perturbations in tissue mechanics promote pathological inflammation and contribute to diseases ranging from asthma and arthritis to heart disease and atherosclerosis.
One aspect I find particularly compelling is the concept of mechanoinflammatory drift during aging, which reflects the gradual accumulation of mechanical and inflammatory dysfunction that drives tissue decline across the lifespan.
I would like to thank my supervisors Carsten Gram Hansen and Steve Jenkins for their invaluable contributions and support throughout this work.
I am also grateful to the reviewers and the editorial team at JEM for their constructive feedback and enthusiasm in helping bring this idea to fruition.”
Title: Mechanobiology of inflammation: Pulling the strings of innate immunity
Authors: Marcin Krzysztof Maniak, Stephen J. Jenkins, Carsten Gram Hansen
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