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Manabu Inoue: Tenecteplase or Alteplase Before Thrombectomy by T-FLAVOR Trial
Manabu Inoue/LinkedIn
Jul 24, 2026, 03:44

Manabu Inoue: Tenecteplase or Alteplase Before Thrombectomy by T-FLAVOR Trial

Manabu Inoue, Chief Medical Officer at Pharmaceuticals and Medical Devices Agency (PMDA), shared on LinkedIn about a recent article he and his colleagues co-authored, published in JAMA Neurology, adding:

”I am pleased to share that the T-FLAVOR trial has been published in JAMA Neurology.

T-FLAVOR is a multicenter, randomized clinical trial comparing tenecteplase with the approved Japanese low-dose alteplase (0.6 mg/kg) before endovascular thrombectomy in patients with acute ischemic stroke.

To our knowledge, this is the first randomized trial to evaluate these two thrombolytic strategies in Japan.

I am sincerely grateful to all investigators, study coordinators, patients, and their families for making this study possible.

I hope these findings will contribute to improving stroke care and advancing evidence-based treatment worldwide.”

Title: Standard-Dose Tenecteplase vs Low-Dose Alteplase for Acute Ischemic Stroke From Large-Vessel Occlusion. A Randomized Clinical Trial

Authors: Manabu Inoue, Teruyuki Hirano, Mayumi Fukuda-Doi, Hiroyuki Kawano, Kenta Tanaka, Nobuyuki Sakai, Masatoshi Koga, Koji Iwasaki, Tomohide Yoshie, Naruhiko Kamogawa, Masafumi Ihara, Tsuyoshi Ohta, Masaki Chin, Naoto Kimura, Kazumi Kimura, Yohei Tateishi, Tadashi Terasaki, Taketo Hatano, Takahiro Kuwashiro, Shinichi Yoshimura, Toshihiro Ueda, Eiichiro Nagata, Yoshinari Nagakane, Shinichi Takahashi, Fumio Miyashita, Kazutaka Sonoda, Kenji Fukuda, Kanta Tanaka, Yoshiko Une, Shigetaka Kobari, Takehiko Nagao, Makoto Sasaki, Haruko Yamamoto, Kazunori Toyoda for the T-FLAVOR trial Investigators

Manabu Inoue: Tenecteplase or Alteplase Before Thrombectomy by T-FLAVOR Trial

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Alteplase Eiichiro Nagata Fumio Miyashita Haruko Yamamoto Health Hematology Hemostasis Hemostasis News Hemostasis Today Hiroyuki Kawano JAMA Neurology Kanta Tanaka Kazumi Kimura Kazunori Toyoda Kazutaka Sonoda Kenji Fukuda Kenta Tanaka Koji Iwasaki Makoto Sasaki Manabu Inoue Masafumi Ihara Masaki Chin Masatoshi Koga Mayumi Fukuda-Doi Medicine Naoto Kimura Naruhiko Kamogawa Nobuyuki Sakai Shigetaka Kobari Shinichi Takahashi Shinichi Yoshimura stroke T-FLAVOR Tadashi Terasaki Takahiro Kuwashiro Takehiko Nagao Taketo Hatano Teruyuki Hirano Thrombectomy Thrombolysis thrombosis Tomohide Yoshie Toshihiro Ueda Tsuyoshi Ohta Yohei Tateishi Yoshiko Une Yoshinari Nagakane
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