Paschalis Karakasis: Anticoagulation Management in Frail Older Adults
Paschalis Karakasis, Cardiologist, Doctor of Philosophy at Aristotle University of Thessaloniki (AUTH), shared a post on LinkedIn about his recent article, published in European Heart Journal, adding:
“I am pleased to share a new publication in the European Heart Journal
‘To switch or not to switch: rethinking anticoagulation in frail elderly patients’
This article addresses an increasingly relevant clinical question: should frail older patients with atrial fibrillation who remain clinically stable on warfarin be routinely switched to a direct oral anticoagulant?
Although DOACs are generally preferred in contemporary practice, replacing an effective and well-tolerated anticoagulation strategy is not necessarily a neutral intervention. Decisions should account for anticoagulation quality, renal function, frailty, bleeding risk, adherence, appropriate dosing, and the individual reasons prompting a treatment change.
The key message is that treatment decisions should not be driven solely by therapeutic novelty.
In frail elderly patients who are doing well on warfarin, individualized assessment remains essential: the best anticoagulant is not necessarily the newer one, but the one that best fits the patient.”
Title: To switch or not to switch: rethinking anticoagulation in frail elderly patients
Authors: Paschalis Karakasis
Stay updated on all scientific advances with Hemostasis Today.
-
Sep 20, 2026, 13:29Factor XI Deficiency and the Challenge of Unpredictable Bleeding – EHC
-
Sep 20, 2026, 13:18Cindy Howry: FDA Approves First Treatment for Ataxia-Telangiectasia
-
Sep 20, 2026, 13:08Mohammad Salar Amoli: When Routine Coagulation Tests Miss von Willebrand Disease
-
Sep 20, 2026, 12:55Stelios AndreadisÖ‰ Human Salivary Gland Organoids Offer New Potential for Regenerative Medicine
-
Sep 20, 2026, 12:43Obi Light Ogbonnia: The Power of Lived Experience in Sickle Cell Care
-
Sep 20, 2026, 12:34Sabrine Mekni: Advancing HSCT for Children With Fanconi Anemia
-
Sep 20, 2026, 12:11Giacomo Buso: Silent Atherosclerosis Begins Earlier Than Expected
-
Sep 20, 2026, 12:0310 Posts Not to Miss This Week
-
Sep 20, 2026, 11:27Edward Lee Carter: Prasugrel Dosing Matters in P2Y12 Inhibitor Comparisons After PCI