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A Rare Case of Glanzmann Thrombasthenia and VWD in the Same Patient – Glanzmann’s Research Foundation
Photo: curegt.org
Aug 12, 2026, 23:16

A Rare Case of Glanzmann Thrombasthenia and VWD in the Same Patient – Glanzmann’s Research Foundation

Glanzmann’s Research Foundation shared a post on LinkedIn about a recent article by Yang Zhang et al., published in RPTH Journal, adding:

“New research highlights an extremely rare case of Glanzmann Thrombasthenia (GT) and Von Willebrand Disease (VWD) occurring in the same patient.

After severe gastrointestinal bleeding did not respond adequately to platelet transfusion, additional testing revealed VWD alongside the patient’s existing GT diagnosis. Researchers later identified separate genetic abnormalities associated with each condition.

The takeaway isn’t that VWD is common in people with GT. It’s that persistent, disproportionate, or unusual bleeding may sometimes warrant looking beyond an existing diagnosis.”

Title: Dual hemostatic defects in Glanzmann thrombasthenia and von Willebrand disease: functional characterization of ITGA2B and dominant-negative von Willebrand factor variants

Auhtors: Yang Zhang, Takahiro Shima, Ikumi Yamanaka, Saori Ueda, Aoi Nishida, Shinya Ohga, Yosuke Morodomi, Akihiko Numata, Tetsuya Eto, Taisuke Kanaji, Takashi Okamura, Koji Kato, Koichi Akashi, Yuya Kunisaki, Sachiko Kanaji

Glanzmann's Research Foundation

Other posts featuring Glanzmann’s Research Foundation on Hemostasis Today.

Akihiko Numata Aoi Nishida bleeding bleeding disorders Blood Gastrointestinal Bleeding Glanzmann thrombasthenia Glanzmann's Research Foundation GT Health Hematology Hemostasis Hemostasis News Hemostasis Today Ikumi Yamanaka Koichi Akashi Koji Kato Medicine Platelet transfusion Sachiko Kanaji Saori Ueda Shinya Ohga Taisuke Kanaji Takahiro Shima Takashi Okamura Tetsuya Eto Von Willebrand Disease VWD Yang Zhang Yosuke Morodomi Yuya Kunisaki
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