Weight Loss with GLP-1s in Everyday Care: Vanderbilt Study Shows Gaps vs. Clinical Trials
Michael Albert, Co-Founder, Chief Medical Officer at Accomplish Health posted on X:
”Real-World GLP-1 Data: Vanderbilt Obesity Clinic Study (n=2,306)
Clinical trials showed 15–21% weight loss with semaglutide and tirzepatide. But how do patients actually fare in practice?
Key Findings:
Median treatment duration: 10.7 months (50% discontinued by 12 months)
Only 23% reached semaglutide 2.4 mg, 28% reached tirzepatide 15 mg
Weight loss for those who continued treatment:
• 6 months: –9.4%
• 12 months: –14.4%
13.6% had medication-related ER visits (mostly GI side effects)
Context:
This was not a typical setting—patients had multidisciplinary support and NO-COST medication access through employer insurance bundles.
Reality Check:
– With the right care model, real-world outcomes can approach RCTs
– Most patients never reach target doses
– Half stop treatment within a year
The gap between “can work” and “does work” remains large. Sustained success appears tied to comprehensive care models that most patients can’t easily access.”
Read the full study here.
Stay updated with Hemostasis Today.
-
Sep 6, 2026, 18:17Aryabhatta Sadhu: Irradiation of Blood Components – From Clinical Indication to Laboratory Release
-
Sep 6, 2026, 18:15Ashenafi Tazebew Amare: A Year of Progress, Transformation and Renewed Commitment
-
Sep 6, 2026, 18:13Emilio Osorio: Can Anticoagulation Be Safely Discontinued After Surgical Left Atrial Appendage Occlusion?
-
Sep 6, 2026, 18:11Razan Alolyani: Our Research on Anticoagulation After Acute Ischemic Stroke Receives 2nd Place
-
Sep 6, 2026, 18:10Chayakrit Krittanawong: Have You Heard of Blood Clots in the Legs?
-
Sep 6, 2026, 18:08Trilok Chand: Microplastics Found in Human Testes and Blood Clots
-
Sep 6, 2026, 18:07Sarah Moharem Elgamal: Cardiovascular Imaging Beyond Anatomy Toward Earlier Risk Prediction
-
Sep 6, 2026, 16:41Christina (Tina) P.: APS – How it Happens in Your Blood, the Warning Signs, and What to Do about It
-
Sep 6, 2026, 16:33Jose Angel Nicolas Avila: How Tissue Mitochondrial Activity Dictates Macrophage Pool Size