Weight Loss with GLP-1s in Everyday Care: Vanderbilt Study Shows Gaps vs. Clinical Trials
Michael Albert, Co-Founder, Chief Medical Officer at Accomplish Health posted on X:
”Real-World GLP-1 Data: Vanderbilt Obesity Clinic Study (n=2,306)
Clinical trials showed 15–21% weight loss with semaglutide and tirzepatide. But how do patients actually fare in practice?
Key Findings:
Median treatment duration: 10.7 months (50% discontinued by 12 months)
Only 23% reached semaglutide 2.4 mg, 28% reached tirzepatide 15 mg
Weight loss for those who continued treatment:
• 6 months: –9.4%
• 12 months: –14.4%
13.6% had medication-related ER visits (mostly GI side effects)
Context:
This was not a typical setting—patients had multidisciplinary support and NO-COST medication access through employer insurance bundles.
Reality Check:
– With the right care model, real-world outcomes can approach RCTs
– Most patients never reach target doses
– Half stop treatment within a year
The gap between “can work” and “does work” remains large. Sustained success appears tied to comprehensive care models that most patients can’t easily access.”
Read the full study here.
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