Shehab Mohamed: A New Regional Consensus on HLH Diagnosis and Management
Shehab Mohamed, Hematologist at Hamad Medical Corporation, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Frontiers in Immunology, adding:
”Here we go !
We share our newly published GCC consensus recommendations for the diagnosis and management of hemophagocytic lymphohistiocytosis (HLH) in Frontiers in Immunology.
This work represents the first GCC-specific consensus framework for HLH, developed to address the unique diagnostic and therapeutic challenges encountered across our region in both adult and pediatric patients.
A multidisciplinary panel of 15 experts representing all GCC countries evaluated 40 clinical statements using a modified Delphi approach. All 40 recommendations achieved consensus in the first round, with 80–100 percent agreement.
The recommendations emphasize early recognition of suspected HLH, appropriate use of HLH-2004 criteria and HScore alongside clinical judgment, parallel investigation for underlying triggers, early genetic assessment when indicated, individualized risk-adapted treatment, and timely referral to centers with ICU and transplant capabilities.
Importantly, the consensus provides a practical regional framework to help harmonize HLH recognition, treatment, referral, transplant planning, and coordination across GCC countries, while also identifying priorities for future regional research.
Many thanks to Mohamed A. Yasin and all colleagues across the GCC for their leadership, collaboration, and dedication to this important work.
It is rewarding to see expertise from across the region come together to advance the care of patients with HLH.
This publication represents another step in our ongoing work and interest in HLH.
We look forward to continuing our collaborative research and contributing further evidence to the HLH literature, particularly in regional epidemiology, genetics, treatment strategies, and clinical outcomes, with the ultimate goal of improving the recognition and management of this challenging syndrome.
Consensus recommendations for the diagnosis and management of hemophagocytic lymphohistiocytosis in the Gulf Cooperation Council: a modified Delphi approach.
Frontiers in Immunology, 2026.”
Title: Consensus recommendations for the diagnosis and management of hemophagocytic lymphohistiocytosis in the Gulf Cooperation Council: a modified Delphi approach
Authors: Mohamed A. Yasin, Muna Al Rasheed, Murtadha Al Khabori, Yasser Wali, Abdelaziz Fahem, Afaf Al Battah, Cigdem Pala Ozturk, Hani Yousif Osman, Maha Sabkar, Mahmoud Marashi, Mozah Al Marshoodi, Nisreen Khalifa, Shehab Mohamed, Salam Al Kindi, Tarek E. Abouzeid
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