Nico Gagelmann: iMTSS to Dissect the Drivers of Post-Transplant Outcomes
Nico Gagelmann, Physician at University Medical Center Hamburg-Eppendorf, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Transplantation and Cellular Therapy, adding:
“What does overall survival actually tell us about why a patient is at risk?
In the largest genomically annotated myelofibrosis transplant cohort to date (n=1,550), we developed and validated iMTSS to dissect the drivers of post-transplant outcomes.
The aim is to move beyond estimating survival toward understanding what drives an individual patient’s risk. To improve understanding and future study designs.
Key findings:
- Relapse was primarily driven by disease biology: particularly TP53 allelic state, alongside RAS pathway mutations, ASXL1, driver genotype, blasts, and blood counts.
- Non-relapse mortality was driven by a distinct set of patient and transplant factors, including performance status, donor type, age, and portal vein thrombosis.
- These two risk dimensions were nearly independent.
- Integrating both dimensions, iMTSS outperformed established disease- and transplant-specific prognostic systems for overall survival.”
Title: iMTSS: an integrated framework for biology- and patient-driven prognosis in myelofibrosis undergoing transplantation
Authors: Nico Gagelmann, Rachel B. Salit, Thomas Schroeder, Patrizia Chiusolo, Maria Chiara Finazzi, Carmelo Gurnari, Simona Pagliuca, Christina Rautenberg, Marie-Thérèse Rubio, Jaroslaw P. Maciejewski, Alessandro Vannucchi, Paola Guglielmelli, Chiara Nozzoli, Nils Leimkühler, Emanuele Angelucci, Massimiliano Gambella, Alessandro Rambaldi, Hans Christian Reinhardt, Andrea Bacigalupo, Bart L. Scott, Florian H. Heidel, Uday Popat, Nicolaus Kröger
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