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Emicizumab for Refractory GI Bleeding in Myeloma-Associated Acquired VWD – JTH
Sep 21, 2026, 20:54

Emicizumab for Refractory GI Bleeding in Myeloma-Associated Acquired VWD – JTH

Journal of Thrombosis and Haemostasis (JTH) shared a post on LinkedIn about a recent article by Milan Vujčić et al., adding:

“Multimodal management of refractory gastrointestinal bleeding in myeloma-associated acquired von Willebrand syndrome: a role for emicizumab prophylaxis

A 72-year-old woman with IgG kappa myeloma and gastrointestinal angiodysplasia had recurrent life-threatening bleeding refractory to factor concentrates, immunoglobulin, plasmapheresis and endoscopy.

Subcutaneous emicizumab with octreotide and ongoing anti-myeloma therapy achieved complete cessation of bleeding despite persistently undetectable von Willebrand factor activity, with 12 months transfusion-free and ECOG 0.”

Title: Multimodal management of refractory gastrointestinal bleeding in myeloma-associated acquired von Willebrand syndrome: a role for emicizumab prophylaxis

Authors: Milan Vujčić, Sanja Madunić, P. Jasminka Jakelić, Marija Petrić, Davor Galušić, Ena Ranković, Ana Boban

JTH

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