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Sam Tsimikas: Lp(a) and Oxidized Phospholipids Link Lipoprotein Biology to Platelet Activation
Sep 25, 2026, 17:13

Sam Tsimikas: Lp(a) and Oxidized Phospholipids Link Lipoprotein Biology to Platelet Activation

Sam Tsimikas, Professor of Medicine at the University of California, San Diego, shared a post on X։

”Lp(a) carries biologically active oxidized phospholipids (OxPL).

New research links its OxPL cargo to platelet hyperactivation through CD36, connecting Lp(a) biology to thrombosis and highlighting the importance of what the particle carries.

Lp(a) may be more involved in platelet function that previously appreciated, see our review on this also.”

Title 1: Lipoprotein(a), platelet function and cardiovascular disease

Authors: Harpreet S Bhatia, Richard C Becker, Gregor Leibundgut, Mitul Patel, Paul Lacaze, Andrew Tonkin, Jagat Narula, Sotirios Tsimikas

Read the Full Article on Nature Reviews Cardiology

Sam Tsimikas: Lp(a) and Oxidized Phospholipids Link Lipoprotein Biology to Platelet Activation

Title 2: Lipoprotein(a) Drives Platelet Hyperactivity Through Oxidized Phospholipids-CD36

Authors: Emily Horner, Lih T. Cheah, Thomas Palmer-Dench, Jawad S. Khalil, Mary McKay, Fraser L. Macrae, Mark T. Kearney, Amanda J. Unsworth, Khalid M. Naseem

Read the Full Article on Circulation Research

Sam Tsimikas: Lp(a) and Oxidized Phospholipids Link Lipoprotein Biology to Platelet Activation

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