Renzo Mancuso: Human Stem Cell Model Reveals Progenitor Fate in Tissue Macrophages
Renzo Mancuso, Group leader at VIB Center for Molecular Neurology, shared a post on LinkedIn about a recent article by Anna Martinez-Muriana et al, published in Developmental Cell, adding:
“Very happy to see this work now online in Developmental Cell!
In this study, we developed a human stem-cell-based system to recreate an early stage of myeloid development and test how these cells behave after transplantation.
We found that a yolk sac-like progenitor population can give rise to different tissue-resident macrophages depending on the organ they enter, including microglia and border-associated macrophages in the brain, as well as macrophages in the liver, heart, and kidney.
One of the most exciting aspects is what this could mean for cell replacement. If developmental origin helps determine how a macrophage behaves, then generating the right progenitor may be essential if we eventually want to replace dysfunctional macrophage populations in disease.
This opens up a lot of questions we are very keen to pursue, including in neurodegenerative disorders where microglia play an important role.
A huge thank you to everyone involved in this collaborative effort, especially Anna Martínez Muriana and Nicola Fattorelli, and all collaborators in VIB-UAntwerp Center for Molecular Neurology and VIB-KU Leuven Center For Neuroscience for bringing all the different pieces of this story together.”
Title: Inducible human yolk sac myeloid progenitors model myeloid ontogeny and enable tissue-resident macrophage replacement in vivo
Authors: Anna Martinez-Muriana, Nicola Fattorelli, Leen Wolfs, Lena Jutz, Emanuela Pasciuto, Heidi Denton, Maxim van Hoek, Jessie Premereur, Gaia Zen, Baukje Bijnens, Alma Mohebiany, Tim Meese, Arthi Shanmugavadivu, V. Hugh Perry, Bart De Strooper, Renzo Mancuso
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