João Paulo Marochi Telles: Antibiotic Treatment in Febrile Neutropenia
João Paulo Marochi Telles, ID Specialist – Antimicrobial TDM at A.C.Camargo Cancer Center, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in International Journal of Antimicrobial Agents, adding:
“Our editorial is out in the International Journal of Antimicrobial Agents (IJAA) (with Birgit Koch)!
We did not try to settle the debate about optimizing antibiotics in patients with febrile neutropenia we tried to name where it goes wrong. Why trials don’t demonstrate significant benefit?
Are we even enrolling the right patients, when a large share of febrile neutropenia episodes never yield a bacterial diagnosis?
When clearance is augmented, is ‘prolonged infusion’ really the best we can offer or does it have to be continuous, and for which CrCl range?
Are endpoints like all cause mortality too blunt to detect what these interventions actually change and what would DOOR capture instead?
In the absence of neutrophils, is 100 percent fT higher MIC still the target or should we be discussing exposure up to 4times MIC?
We do not claim to have resolved these. The editorial is our attempt to put them in the right perspective.”
Thank you Birgit for this colab!
Very nice!”
Title: Antibacterial dose optimisation in patients with febrile neutropenia: Are we targeting the right patients and the right endpoints
Authors: João Paulo Telles, Birgit Koch
Stay updated on all scientific advances with Hemostasis Today.
-
Oct 22, 2026, 03:40Hussein Burestom: Blood and Plasma as Strategic Resources for National Health Security
-
Oct 21, 2026, 18:13Wolfgang Miesbach: Hereditary Hemorrhagic Telangiectasia An Overlooked Bleeding Disorder
-
Oct 21, 2026, 17:55Gayatri Kotwal։ New Review on Anemia, Pain, and Nutritional Deficiencies in Cancer Patients
-
Oct 21, 2026, 17:40Tetsuzan Ron: Iron Deficiency Without Anemia Clinical Impact and Management
-
Oct 21, 2026, 17:29Amir Hossien Esfandiari։ The Association Between Viral Infections and Aplastic Anemia
-
Oct 21, 2026, 17:16Melissa Hollo: A Meaningful Step Forward for Women’s Health
-
Oct 21, 2026, 17:09Chipili Ng’onga: Have You Ever Seen a Result That Just Didn’t Make Sense?
-
Oct 21, 2026, 16:57Fabrice Cognasse: Celebrating the Next Generation of Platelet Research and Transfusion Medicine
-
Oct 21, 2026, 16:47Christabel Odeta: Treating Pediatric Cancer in Children With Sickle Cell Disease