Stefano Navarro: Hypertension Reprogrammes Megakaryocytes and Increases Platelet Responsiveness to Thrombin
Stefano Navarro, Postdoctoral Researcher at Rudolf Virchow Center of University of Würzburg, shared a post on LinkedIn:
“Hypertension is usually discussed in terms of blood pressure, but what does its inflammatory environment do to platelets?
Based on the work of Wang et al., ehj, 2026, In our editorial in the European Heart Journal, Bernhard Nieswandt and I discuss new evidence that hypertension can reprogramme megakaryocytes, increasing PAR4 on newly formed platelets and making them more responsive to thrombin.
We also consider what this could mean for thrombotic risk and the potential relevance of the use of valsartan in hypertension.
It was a real pleasure to write this editorial.”
Title 1: Angiotensin II-driven TGF-β1 increases platelet PAR4 expression enhancing thrombotic risk in hypertension
Authors: Mingzhu Wang, Zixian Liu, Yufei Chen, Shufang Wang, Yongbo Ma, Jiaorui Wang, Ke Zheng, Mingjie Li, Meiling Wu, Zhichao Fan, Yunfeng Chen, Dongchao Lu, Jian Li, Haidong Guo, Deyu Fu, Liang Hu
Read the Full Article on European Heart Journal
Title 2: When platelets are under pressure: an angiotensin II-TGF-β axis in hypertensive patients leads to receptor PAR4 overexpression
Authors: Stefano Navarro, Bernhard Nieswandt
Read the Full Article on European Heart Journal
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