Alexandros Makis: 20-year Cohort of 112 Children with Autoimmune Neutropenia
Alexandros Makis, Professor of Pediatrics/Pediatric Hematology at Faculty of Medicine, School of Health Sciences, University of Ioannina, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in British Journal of Haematology, adding:
“I am pleased to share our latest publication in the British Journal of Haematology.
In a 20-year cohort of 112 children with autoimmune neutropenia, we confirmed that it isn’t one condition — it’s three distinct phenotypes with very different paths: Primary autoimmune neutropenia — benign, resolving in nearly 19 months despite very low neutrophil counts.
Long-lasting neutropenia — strong familial autoimmunity, delayed resolution (nearly 67 months).
Late-onset neutropenia — multi-lineage lymphopenia, frequent ANA positivity and associated autoimmune disease, yet no severe infection-related hospitalisations.
A paradox explained by preserved humoral immunity.
These findings support phenotype-based stratification as a tool for improving clinical monitoring and management of childhood autoimmune neutropenia.
Grateful to my co-authors Ioanna Saougou, Chrysoula Kosmeri, Nikolaos Chaliasos, Irene Mavroudi and Charalampos Pontikoglou and to the families whose long-term follow-up made this work possible.”
Title: Phenotype-specific immune profiles and outcomes in childhood autoimmune neutropenia: A 20-year cohort study
Authors: Ioanna Saougou, Chrysoula Kosmeri, Nikolaos Chaliasos, Irene Mavroudi, Charalampos Pontikoglou, Alexandros Makis
Stay updated on all scientific advances with Hemostasis Today.
-
Sep 29, 2026, 19:00Caitlin Raymond: Can Artificial Blood Solve Blood Supply Shortages?
-
Sep 29, 2026, 18:51Chaza Alaji: Dyslipidemia, Thrombosis and the DIC Diagnostic Trap
-
Sep 29, 2026, 17:31Rajnikant Patel: Bridging Ayurvedic Concepts and Modern Toxin-Mediated Disease
-
Sep 29, 2026, 17:13Nicholas Lang։ A Meaningful Case of Immune Thrombocytopenia
-
Sep 29, 2026, 16:55Ayatullah Gamal Wahab: When the CBC Lies
-
Sep 29, 2026, 16:35Jonathan Douxfils: Navigating the VTE Risk Continuum in Reproductive Medicine
-
Sep 29, 2026, 16:35Chaima Rajeh: Types of Anemia and Their Laboratory Features
-
Sep 29, 2026, 16:27Scott Isaacs: How GLP-1 RAs Target Systemic Inflammation to Drive Cardio, Autoimmune, and Gut Health
-
Sep 29, 2026, 16:21Yitshak Kreiss: From Treating Patients to Defining the Standard of Knowledge