Deepak Lodha: PT and aPTT Mixing Study is a Key Tool in Coagulation Diagnosis
Deepak Lodha, Lab Technician at Dr Lal PathLabs, shared a post on LinkedIn:
“PT and aPTT Mixing Study – A Key Tool in Coagulation Diagnosis
In routine laboratory practice, prolonged PT or aPTT often creates diagnostic confusion.
Is it a factor deficiency or the presence of a circulating inhibitor?
This is where the Mixing Study becomes essential.
By mixing patient plasma with normal plasma (1:1) and reassessing clotting time, we can identify the underlying cause:
- Correction of PT/aPTT suggests factor deficiency. Seen in conditions like Vitamin K deficiency, liver disease, Hemophilia, or early DIC
- No correction ndicates presence of inhibitor, such as Lupus anticoagulant, Factor VIII inhibitor, or heparin effect
Incubated mixing study further helps detect time-dependent inhibitors, which may not be evident immediately.
This simple yet powerful test:
- Improves diagnostic accuracy
- Guides appropriate treatment (factor replacement vs inhibitor management)
- Prevents unnecessary transfusions
In coagulation testing, correct interpretation is just as important as performing the test. Always correlate with clinical findings and additional tests like TT, fibrinogen, and D-dimer.”
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