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Deepak Lodha: PT and aPTT Mixing Study is a Key Tool in Coagulation Diagnosis
Deepak Lodha/LinkedIn
May 10, 2026, 15:13

Deepak Lodha: PT and aPTT Mixing Study is a Key Tool in Coagulation Diagnosis

Deepak Lodha, Lab Technician at Dr Lal PathLabs, shared a post on LinkedIn:

“PT and aPTT Mixing Study – A Key Tool in Coagulation Diagnosis

In routine laboratory practice, prolonged PT or aPTT often creates diagnostic confusion.

Is it a factor deficiency or the presence of a circulating inhibitor?

This is where the Mixing Study becomes essential.

By mixing patient plasma with normal plasma (1:1) and reassessing clotting time, we can identify the underlying cause:

  • Correction of PT/aPTT suggests factor deficiency. Seen in conditions like Vitamin K deficiency, liver disease, Hemophilia, or early DIC
  • No correction ndicates presence of inhibitor, such as Lupus anticoagulant, Factor VIII inhibitor, or heparin effect

Incubated mixing study further helps detect time-dependent inhibitors, which may not be evident immediately.

This simple yet powerful test:

  • Improves diagnostic accuracy
  • Guides appropriate treatment (factor replacement vs inhibitor management)
  • Prevents unnecessary transfusions

In coagulation testing, correct interpretation is just as important as performing the test. Always correlate with clinical findings and additional tests like TT, fibrinogen, and D-dimer.”

Deepak Lodha

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aPTT bleeding disorders Blood coagulation D dimer Deepak Lodha DIC Factor VIII inhibitor fibrinogen Health Hematology Hemophilia Hemostasis Hemostasis News Hemostasis Today Heparin Liver Disease Lupus Anticoagulant Medicine PT TT Vitamin K deficiency
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