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Glen Pyle: Association Between Premature Menopause and Coronary Heart Disease Risk
Priya M. Freaney and Glen Pyle
Mar 19, 2026, 15:16

Glen Pyle: Association Between Premature Menopause and Coronary Heart Disease Risk

Glen Pyle, Professor, Member of Women’s Health Research Institute (WHRI) and of IMPART, shared a post on LinkedIn about a recent article by Priya M. Freaney et al. published in JAMA Cardiology:

“Menopause increases women’s cardiovascular disease risk and women who experience menopause before age 40 have an even higher risk.

A new study in JAMA Cardiology investigated the connection between premature menopause and coronary heart disease, and found Black women were threefold more likely than White women to enter menopause before age 40 (15.5% vs 4.8%).

The risk of coronary heart disease in these women was 40% higher than women who entered menopause after age 40, regardless of racial background.

Earlier studies have demonstrated a link between early (<45 years of age) and premature (<40 years of age) menopause with coronary heart disease within 7 years of menopause.

This study looked at a significantly longer window of risk (~30 years) and shows that the elevated risk persists.

While menopause is typically seen as a ‘reproductive’ issue best dealt with by gynecology professionals, this study by Priya M. Freaney and colleagues underscores the need for women, family physicians, and cardiologists to consider reproductive history in assessing cardiovascular disease risk.

Clear communication about patient history, risk factors, and strategies to mitigate cardiovascular risks are critical for ensuring a long and healthy life for women.”

Title: Premature Menopause and Lifetime Risk of Coronary Heart Disease

Authors: Priya M. Freaney, Hongyan Ning, Mercedes Carnethon, John T. Wilkins, Norrina B. Allen, Donald M. Lloyd-Jones, Sadiya S. Khan

Read the Full Article on JAMA Cardiology

Glen Pyle: Association Between Premature Menopause and Coronary Heart Disease Risk

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cardiovascular disease risk Coronary Heart Disease Donald M. Lloyd-Jones Glen Pyle Health Hematology Hemostasis Hemostasis News Hemostasis Today Hongyan Ning JAMA Cardiology John T. Wilkins. Medicine Menopause Mercedes Carnethon Norrina B. Allen Priya M. Freaney Sadiya S. Khan
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