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Hisam Siddiqi: Is FFP Really The Magic Elixir of All Coagulopathies in Liver Disease?

Hisam Siddiqi/LinkedIn

Mar 13, 2026, 13:10

Hisam Siddiqi: Is FFP Really The Magic Elixir of All Coagulopathies in Liver Disease?

Hisam Siddiqi, Consultant Haematologist at LycaHealth, The Blackheath Hospital, Dartford and Gravesham NHS Trust, shared a post on LinkedIn:

“‘Is FFP really the magic elixir of all coagulopathies in Liver Disease‘

Every. Single. Day.
24/7 — 365.
Some colleagues still believe FFP is a magic bullet that will sort out any abnormal coagulation result.

But in Haematology, very few things are absolute. Almost everything lives in relative territory — especially in haemostasis.

And pouring industrial volumes of FFP into a patient to ‘chase’ a number…

Let’s just say it’s borderline high treason in our world.

I hope this extract I’ve put together from BSH guidance helps colleagues understand when to ask for FFP and when absolutely not to.

Because…

Alcohol‑related liver disease (ALD) and other chronic liver conditions aren’t going anywhere in the Western world.
But that doesn’t mean we should waste vast quantities of FFP just because we feel uncomfortable with the numbers.
The INR in liver disease is a reflection of synthetic dysfunction, not a target to normalise with plasma.

Let’s cascade this message to our trainees and teams — it’s a small learning point that prevents a huge amount of unnecessary transfusion, risk, and resource use.

Would love to hear your thoughts — drop them below!

Humour very welcome. Education essential.”

Hisam Siddiqi
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