Kato Ramaekers: Redefining Integrin αIIbβ3 in Platelet Formation
Kato Ramaekers, PHD Student at Center for Molecular and Vascular Biology, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in Blood, adding:
“Thrilled to share that my latest work just got published in Blood.
We challenged the traditional view of integrin αIIbβ3 as solely an aggregation receptor. Our data shows it plays a quantitative role in platelet formation, with both deficiency and hyperactivity leading to reduced output. We found a novel connection between platelet formation and serine metabolism in megakaryocytes.
Grateful to everyone who contributed to this paper.”
Title: Reduced platelet formation associated with serine metabolic dysregulation in integrin αIIbβ3–deficient megakaryocytes
Authors: Kato Ramaekers, My Tran, Marco Lunghi, Amy Hermans, Chantal Thys, Koenraad De Wispelaere, Ernest Turro, Chris Van Geet, Quentin Van Thillo, Kathelijne Peerlinck, Koji Eto, Alan T. Nurden, Alessandra Balduini, Christian A. Di Buduo, Veerle Labarque, Kathleen Freson
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